Num 26 October 2008.    POLIBOTANICA 26:139-152

ISSN 1405-2768

CYTOTOXICITY IN HELA CELLS FROM EXTRACTS OF THREE MEDICINAL PLANTS SPECIES FROM HIDALGO, MEXICO

M.A. Villavicencio Nieto, B.E. Pérez Escandón, E. Mendoza Pérez

Laboratorio de Etnobotánica. Centro de Investigaciones Biológicas Universidad Autónoma del Estado de Hidalgo
Correo electrónico: mavn3@hotmail.com

V. Maldonado Lagunas

Instituto Nacional de Cancerología

ABSTRACT

Ethanolic extracts of three medicinal plants, Juniperus deppeana, Solanum rostratum and Bidens odorata, which are used in folk medicine in Hidalgo, Mexico, for the treatment of wounds, ulcers, tumors and cancer, were tested in a HeLa cell line to evaluate their cytotoxic activity. The highest cytotoxicity was found in the extract of J. deppeana (IC50 = 4.63 µg/ml); hence, this extract was separated via chromatography on a silica gel plate, from which the main fraction (Rf = 0.28) showed strong cytotoxic activity (IC50 = 0.79 µg/ml). Whereas the extract of S. rostratum also exhibited cytotoxicity (IC50 = 127.5 µg/ml), that of B. odorata was inactive.

Key words: Juniperus deppeana, Solanum rostratum, Bidens odorata, medicinal plants, Hidalgo, Mexico, cytotoxicity, HeLa.

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